Peptide Utility (PU) search server: A new tool for peptide sequence search from multiple databases
Tanishq Chamoli, Alisha Khera, Akanksha Sharma, Anshul Gupta, Sonam Garg, Kanishk Mamgain, Aayushi Bansal, Shriya Verma, Ankit Gupta, Hema Kumari Alajangi, Gurpal Singh, Ravi Pratap Barnwal
Abstract
Proteins are essential building blocks in humans that have garnered huge attention from researchers worldwide due to their numerous therapeutic applications. To date, different computational tools have been developed to extract pre-existing information on these biological molecules, but most of these tools suffer from limitations such as non-user friendly interface, redundancy of data, etc. To overcome these limitations, a user-friendly interface, the Peptide Utility (PU) webserver (https://chain-searching.herokuapp.com/) has been developed for searching and analyzing homologous and identical protein/peptide sequences that can be searched from approximately 0.4 million sequences (structural and sequence information) in both online and offline modes. The PU web server can also be used to study different types of interactions in PDBSum, identifying the most dominating interface residues, the most prevalent interactions, and the interaction preferences of different residues. The webserver would also pave way for the design of novel therapeutic peptides and folds by identifying conserved residues in the three-dimensional structure space of proteins.