Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects
Elias Eteshola, Karenia Landa, Rachel E. Rempel, Ibtehaj A. Naqvi, E. Shelley Hwang, Smita K. Nair, Bruce A. Sullenger
Abstract
. Notably, treatment with the polyamidoamine dendrimer generation 3.0 (PAMAM-G3) behaved as a nucleic acid scavenger (NAS) and significantly mitigates such effects. In mice that develop spontaneous BC induced by polyoma middle T oncoprotein (MMTV-PyMT), treatment with PAMAM-G3 significantly reduces lung metastasis. Thus, NAS treatment mitigates cancer-induced inflammation and metastasis and represents a novel therapeutic approach for combating breast cancer.
Topics & Concepts
TLR9Triple-negative breast cancerCancer researchBreast cancerMetastasisMalignancyNucleic acidCancerChemotherapyCellCancer cellMedicineBiologyImmunologyInternal medicineDNA methylationBiochemistryGeneticsGene expressionGeneImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancer