Evaluation of Omadacycline Alone and in Combination with Rifampin against Staphylococcus aureus and Staphylococcus epidermidis in an <i>In Vitro</i> Pharmacokinetic/Pharmacodynamic Biofilm Model
Taylor Morrisette, Kyle Stamper, Katherine L. Lev, Razieh Kebriaei, Dana Holger, Jacinda C. Abdul‐Mutakabbir, Ashlan J. Kunz Coyne, Michael J. Rybak
Abstract
reductions from starting inoculum in strains in which bactericidal activity was reached). Furthermore, OMC was shown to prevent the emergence of RIF resistance. Our data provide preliminary evidence that OMC in combination with RIF could be a viable option for biofilm-associated infections with S. aureus and S. epidermidis. Further research involving OMC in biofilm-associated infections is warranted.
Topics & Concepts
Staphylococcus epidermidisStaphylococcus aureusBiofilmMicrobiologyIn vitroPharmacodynamicsStaphylococcusPharmacokineticsAntibioticsMicrococcaceaePharmacologyChemistryAntibacterial agentMedicineBiologyBacteriaBiochemistryGeneticsAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaBacterial Identification and Susceptibility Testing