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Levomilnacipran alleviates cyclophosphamide-induced hepatic dysfunction in male Wistar albino rats; emerging role of α-Klotho/TLR4/p38-MAPK/NF-κB p65 and caspase-3-driven apoptosis trajectories

Ehab E Sharata, Mina Ezzat Attya, Marwa M. Khalaf, Remon Roshdy Rofaeil, Amira M. Abo‐Youssef, Ramadan A.M. Hemeida

2025International Immunopharmacology16 citationsDOI

Topics & Concepts

TLR4KlothoApoptosisp38 mitogen-activated protein kinasesNF-κBMAPK/ERK pathwayMedicineCaspaseEndocrinologyInternal medicineCancer researchChemistryBiologySignal transductionKidneyProgrammed cell deathInflammationCell biologyBiochemistryChemotherapy-induced organ toxicity mitigationDrug-Induced Hepatotoxicity and ProtectionHematopoietic Stem Cell Transplantation
Levomilnacipran alleviates cyclophosphamide-induced hepatic dysfunction in male Wistar albino rats; emerging role of α-Klotho/TLR4/p38-MAPK/NF-κB p65 and caspase-3-driven apoptosis trajectories | Litcius