Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe
Ning Zhu, Ge Xu, Rongchen Wang, Tianli Zhu, Jiahui Tan, Xianfeng Gu, Chunchang Zhao
Abstract
An activatable and mitochondrial-targetable fluorescent probe was developed. This designed probe showed ratiometric fluorescence and light-up near-infrared emission responsiveness to nitroreductase, achieving precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity.
Topics & Concepts
NitroreductaseFluorescenceCancer cellMitochondrionChemistryCancerCancer imagingBiophysicsCancer researchBiochemistryMedicineEnzymeBiologyOpticsInternal medicinePhysicsMolecular Sensors and Ion DetectionNanoplatforms for cancer theranosticsSulfur Compounds in Biology