Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy
He Ding, Jinhu Chang, Fei He, Shili Gai, Piaoping Yang
Abstract
Abstract Advances in nanotechnology have enabled the rapid development of stimuli‐responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S‐responsive properties, as new‐generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state‐of‐art research on H 2 S‐related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S‐mediated gas therapy and H 2 S‐related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real‐time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S‐based therapy that facilitate clinical translation to patients are discussed.