Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice
Tingting Li, Lin Yuan, Yijing Zhao, Zige Jiang, Chengcheng Gai, Danqing Xin, Hongfei Ke, Xiaofan Guo, Wenqiang Chen, Dexiang Liu, Zhen Wang, Cyrus S. H. Ho
Topics & Concepts
NeuroinflammationOsteopontinMicrogliaSmall hairpin RNAGene knockdownProinflammatory cytokineLipopolysaccharideWestern blotCell biologyChemistryBiologyInflammationImmunologyCell cultureBiochemistryGeneticsGeneBone and Dental Protein StudiesTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms