Divergent Synthesis of Four Types of Fused <i>N</i>‐Containing Heterocycles via Oxidative Multi‐Component Cyclization Reaction
Xiaoshuang Guo, Maozhong Miao, Peng Zhao, Yongmin Ma
Abstract
Comprehensive Summary An atmospheric‐oxygen‐mediated four‐component reaction was developed for the divergent synthesis of pyrazolo[1,5‐ a ]pyrimidine and pyrazolo[3,4‐ b ]pyridine derivatives from readily available alcohols and 3‐aminopyrazoles. In this transformation, atmospheric oxygen serves as the green oxidant, promoting alcohols as equivalent aldehydes for the synthesis of four types of N ‐containing heterocycles (> 40 examples). Remarkably, the transformation features metal‐free and molecular diversity.
Topics & Concepts
ChemistryOxidative phosphorylationComponent (thermodynamics)Combinatorial chemistryOrganic chemistryBiochemistryPhysicsThermodynamicsCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques