Adipose derived stem cells – Sources, differentiation capacity and a new target for reconstructive and regenerative medicine
Małgorzata Suchanecka, Joanna Grzelak, Maryam Farzaneh, Shirin Azizidoost, Mahrokh Abouali Gale Dari, Małgorzata Józkowiak, Krzysztof Data, Dominika Domagała, Julia Niebora, Katarzyna Kotrych, Bogusław Czerny, Adam Kamiński, Natalia Torlińska-Walkowiak, Andrzej Bieniek, Jacek C. Szepietowski, Hanna Piotrowska‐Kempisty, Piotr Dzięgiel, Paul Mozdziak, Bartosz Kempisty
Abstract
Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) derived from adipose tissue with mesenchymal lineage differentiation potential and remarkable potential in regenerative medicine. ADSCs are easily sourced from adipose tissue, share regenerative characteristics akin to other MSCs. Their convenient adherence to plastic culture flasks, coupled with their capacity for in vitro expansion and multi-lineage differentiation, underscores their promise as a robust tool for tissue repair and enhancement. The accessibility of human adipose tissue and the development of minimally invasive isolation protocols have further propelled the autologous use of ADSCs, fueling excitement in both organ repair and regenerative medicine. Consequently, research in ADSCsis experiencing rapid growth. A detailed overview of the current landscape of ADSCs isolation and differentiation capacity including the latest advancements in ADSCs usage, encompassing ongoing clinical investigations are important considerations to understand their potential to shape the landscape of regenerative medicine.