Minipolymyoclonus: A Critical Appraisal
Jacky Ganguly, Jia Ren Chai, Mandar Jog
Abstract
Minipolymyoclonus is an intriguing clinical phenomenology that is seen in central neurodegenerative and epileptic disorders as well as in AHC disease (primary or secondary) and peripheral nerve hyperexcitability disorders. Our review highlights the knowledge gaps and controversies regarding this interesting phenomenon and highlights the unmet need for more extensive clinical, electrophysiological and radiological correlation studies on the topic. Some unsolved issues regarding the pathophysiology remain open to further debate. It is necessary to consider the clinical setting in which it occurs, the presence of other clinical signs, and the results of electrophysiological studies to navigate through this gray zone of overlap.