Novel Thienopyrimidine-Based PET Tracers for P2Y<sub>12</sub> Receptor Imaging in the Brain
Berend van der Wildt, Bieneke Janssen, Aleksandra Pekošak, E. Johanna L. Stéen, Robert C. Schuit, Esther Kooijman, Wissam Beaino, Daniëlle J. Vugts, Albert D. Windhorst
Abstract
R inhibitors with improved physicochemical characteristics to reduce efflux transport and increase brain penetration.
Topics & Concepts
In vivoPositron emission tomographyMicrogliaChemistryEx vivoPharmacologyP-glycoproteinTranslocator proteinHuman brainBlood–brain barrierReceptorMetaboliteTransporterIn vitroMedicineInternal medicineBiologyNeuroscienceBiochemistryCentral nervous systemNuclear medicineInflammationAntibioticsGeneBiotechnologyMultiple drug resistanceAdenosine and Purinergic SignalingCancer, Stress, Anesthesia, and Immune ResponseNeuropeptides and Animal Physiology