Bumetanide as a Model NDSRI Substrate: N-nitrosobumetanide Impurity Formation and its Inhibition in Bumetanide Tablets
Diaá M. Shakleya, Bethel Asmelash, Alaadin Alayoubi, Nicolas Abrigo, Adil Mohammad, Jiang Wang, Jinhui Zhang, Jingyue Yang, Tim Andres Marzan, David Li, Maha Shaklah, Fahd M. Alsharif, Saaniya Desai, Patrick J. Faustino, Muhammad Ashraf, Thomas O’Connor, Matthew D. Vera, Andre Raw, Vilayat A. Sayeed, David A. Keire
Topics & Concepts
ChemistryNitrosamineDrugImpurityActive ingredientSubstrate (aquarium)BumetanideChromatographyCombinatorial chemistryOrganic chemistryCarcinogenPharmacologySodiumOceanographyCotransporterGeologyMedicineWater Treatment and DisinfectionAsthma and respiratory diseasesAnalytical chemistry methods development