Direct Access to α,β-Unsaturated Ketones via Rh/MgCl<sub>2</sub>-Mediated Acylation of Vinylsilanes
Xuezu Deng, Ziyan Chen, Yang Song, Fei Xue, Motoki Yamane, Yanni Yue
Abstract
We report herein the facile and practical construction of α,β-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.
Topics & Concepts
ChemistryAcylationRhodiumYield (engineering)CatalysisSurface modificationCombinatorial chemistryOrganic chemistryCarboxylic acidMaterials sciencePhysical chemistryMetallurgyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms