Characterization of a robust mouse model of heart failure with preserved ejection fraction
Dzmitry Matsiukevich, Attila Kovács, Tiandao Li, Kristen M. Kokkonen-Simon, Scot J. Matkovich, Sunday S. Oladipupo, David M. Ornitz
Abstract
Heart failure with preserved ejection fraction (HFpEF) is an emerging epidemic affecting up to half of patients with heart failure. Here we used a chronic angiotensin II/phenylephrine (ANG II/PE) infusion model and instituted an updated algorithm for HFpEF assessment. Given the simplicity in generating this model, it may become a useful tool for investigating pathogenic mechanisms, identification of diagnostic markers, and for drug discovery aimed at both prevention and treatment of HFpEF.
Topics & Concepts
Ejection fractionFraction (chemistry)Heart failureInternal medicineCardiologyCharacterization (materials science)MedicineMaterials scienceChemistryChromatographyNanotechnologyCardiovascular Function and Risk FactorsReceptor Mechanisms and SignalingAdipose Tissue and Metabolism