Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
Maureen Lynch, Guerrino Macori, Séamus Fanning, Edel O’Regan, Eoin Hunt, Dermot S. O’Callaghan, Brian McCullagh, Cormac Jennings, Anne E. Fortune
Abstract
We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
Topics & Concepts
SuperinfectionBiologyVirusVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)MedicineDiseaseInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 Impact on Reproduction