Regioselective One-Pot Synthesis and Antioxidant Activity Study of Trichloro Isatins and Dichloro Isatins
Nasrin Karami Hezarcheshmeh, Javad Azizian
Abstract
In this research a new derivatives of 3,3,5-trichloroisatins and 3,3-dichloroisatins were synthesized in good yields using catalyst-free one-pot reaction of isatins or N-alkylisatines, triphenylphosphine and carbon tetrachloride in acetonitrile at room temperature. Because of existing isatin core in synthesized compounds, the antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and comparing the results with synthetic antioxidants (TBHQ and BHT). Easy, simple, fast and new procedure are the some advantages of this study.
Topics & Concepts
ChemistryIsatinRegioselectivityDPPHAcetonitrileOrganic chemistryOne-pot synthesisAntioxidantCarbon tetrachlorideFerricTriphenylphosphineCatalysisSynthesis and biological activitySynthesis of Organic CompoundsSynthesis and Reactivity of Sulfur-Containing Compounds