<i>In Vitro</i> Susceptibility of Thai Pythium insidiosum Isolates to Antibacterial Agents
Navaporn Worasilchai, Ariya Chindamporn, Rongpong Plongla, Pattama Torvorapanit, Kasama Manothummetha, Nipat Chuleerarux, Nitipong Permpalung
Abstract
Human pythiosis is a life-threatening human disease caused by Pythium insidiosum . In Thailand, vascular pythiosis is the most common form and carries a mortality rate of 10 to 40%, despite aggressive treatment with radical surgery, antifungal agents, and immunotherapy. Itraconazole and terbinafine have been the mainstay of treatment, until recently, based on case report data showing potential synergistic effects against Brazilian P. insidiosum isolates. However, the synergistic effects of itraconazole and terbinafine against Thai P. insidiosum isolates were not observed.
Topics & Concepts
TerbinafineItraconazolePythiumMicrobiologyBiologyAntifungalHorticultureInfectious Diseases and MycologyMycobacterium research and diagnosisMyxozoan Parasites in Aquatic Species