Phenolic compounds from the sclerotia of <i>Inonotus obliquus</i>
Yan-Mei Wei, Li Yang, Wen‐Li Mei, Huiqin Chen, Cai-Hong Cai, Wei Li, Wen-Hua Dong, Zhi-Bao Chen, Hao‐Fu Dai
Abstract
Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective activity against oxidative damage on human neuroblastoma SH-SY5Y cells induced by H2O2. Compound 2 showed remarkable neuroprotective effect and significantly improved the cell viability of SH-SY5Y cells treated by H2O2.
Topics & Concepts
Inonotus obliquusNeuroprotectionSH-SY5YChemistryViability assayStereochemistryTraditional medicineBotanyBiochemistryIn vitroBiologyCell cultureNeuroblastomaPharmacologyMedicineGeneticsFungal Biology and ApplicationsPhytochemicals and Antioxidant ActivitiesPolysaccharides and Plant Cell Walls