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Discovery of (S)–N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist

Yue Qiao, Yang Zhang, Zhenrui Qiao, Wenya He, Yingda Chen, Depu Song, Guohao Wang, Ning Guo, Lulian Shao, Zhiyong Tian, Qiang Wang, Yan Lin, Hai Qian

2022European Journal of Medicinal Chemistry20 citationsDOIOpen Access PDF

Topics & Concepts

TRPV1ChemistryAntagonistPharmacologyCarboxamidePenetrant (biochemical)In vivoCapsaicinDocking (animal)StereochemistryReceptorBiochemistryTransient receptor potential channelOrganic chemistryBiotechnologyBiologyMedicineNursingIon Channels and ReceptorsPhytochemicals and Antioxidant ActivitiesPain Mechanisms and Treatments
Discovery of (S)–N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist | Litcius