Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery
Qingqing Xiong, Yujing Li, Kun Zhou, Ping Chen, Hua Guo, Lu Chen, Jianxun Ding, Tianqiang Song, Jinjun Shi
Abstract
Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid-polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.
Topics & Concepts
NanoparticleChemistryPolymerSmall interfering RNANanotechnologyBiochemistryTransfectionMaterials scienceGeneOrganic chemistryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesDendrimers and Hyperbranched Polymers