Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling
Yu Fu, Manjin Zhang, Bing‐Dong Sui, Feifei Yuan, Wenbo Zhang, Yashuang Weng, Lei Xiang, Can Li, Longquan Shao, Yong You, Xueli Mao, Haitao Zeng, Di Chen, Meijia Zhang, Songtao Shi, Xuefeng Hu
Abstract
Our studies reveal a previously unknown association between apoVs and ovarian folliculogenesis and suggest an apoV-based therapeutic approach to improve oocyte function and birth rates in PCOS and aging.
Topics & Concepts
FolliculogenesisMesenchymal stem cellWnt signaling pathwayPolycystic ovaryOvaryStem cellMedicineCancer researchApoptosisCell biologyBiologyInternal medicineEndocrinologySignal transductionInsulin resistanceInsulinBiochemistryEmbryoCryopreservationReproductive Biology and FertilityReproductive System and PregnancyWnt/β-catenin signaling in development and cancer