CD19 CAR T-Cell Therapy in Multidrug-Resistant Ulcerative Colitis
Fabian Müller, Raja Atreya, Simon Völkl, Michael Aigner, Sascha Kretschmann, Soraya Kharboutli, Moritz Leppkes, Selina Sitte, Deike Strobel, Arndt Hartmann, Saurabh Mehandru, Jean–Frédéric Colombel, Georg Schett, Andréas Mackensen, Markus F. Neurath
Abstract
In a patient with treatment-resistant ulcerative colitis, CD19 CAR T-cell therapy led to drug-free remission and mucosal healing, suggesting that B-cell targeting may offer a novel therapeutic pathway.
Topics & Concepts
MedicineUlcerative colitisInternal medicineGastroenterologyCD19ColitisImmunologyTherapeutic approachDiseaseSurgeryCAR-T cell therapy researchT-cell and B-cell ImmunologyInflammatory Bowel Disease