Antibiotic Susceptibility of Clinical Burkholderia pseudomallei Isolates in Northeast Thailand from 2015 to 2018 and the Genomic Characterization of <i>β</i> -Lactam-Resistant Isolates
Shirley Yi Fen Hii, Sarunporn Tandhavanant, Rungnapa Phunpang, Peeraya Ekchariyawat, Natnaree Saiprom, Claire Chewapreecha, Rathanin Seng, Ekkachai Thiansukhon, Chumpol Morakot, Narongchai Sangsa, Sunee Chayangsu, Somchai Chuananont, Kittisak Tanwisaid, Wirayut Silakun, Noppol Buasi, Seksan Chaisuksant, Tanin Hompleum, Ploenchan Chetchotisakd, Nicholas Day, Wasun Chantratita, Ganjana Lertmemongkolchai, T. Eoin West, Narisara Chantratita
Abstract
Melioidosis is an often fatal infection in tropical regions caused by an environmental bacterium, Burkholderia pseudomallei . Current recommended melioidosis treatment requires intravenous β-lactam antibiotics such as ceftazidime (CAZ), meropenem (MEM), or amoxicillin-clavulanic acid (AMC) and oral trimethoprim-sulfamethoxazole.