A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide
Victor Babin, Antoine Sallustrau, Olivier Loreau, Fabien Caillé, Amélie Goudet, Héloïse Cahuzac, Antonio Del Vecchio, Frédéric Taran, Davide Audisio
Abstract
Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including 14C and 11C, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.
Topics & Concepts
Carbon-13ChemistryCarbon dioxideUreaIsotopeCarbon-14Isotopes of carbonCarbon fibersRadiochemistryCompounds of carbonOrganic chemistryChemical reactionPhysicsNuclear physicsMaterials scienceTotal organic carbonComposite numberComposite materialChemical Reactions and IsotopesAmino Acid Enzymes and MetabolismMass Spectrometry Techniques and Applications