Synthesis and photobiological applications of naphthalimide–benzothiazole conjugates: cytotoxicity and topoisomerase IIα inhibition
Iqubal Singh, Vijay Luxami, Diptiman Choudhury, Kamaldeep Paul
Abstract
Conjugates of naphthalimide, benzothiazole, and indole moieties are synthesized that show excellent cytotoxicity against A549 (lung), MCF7 (breast), and HeLa (cervix) cancer cell lines with IC 50 values in the range of 0.14–8.59 μM.
Topics & Concepts
CytotoxicityBenzothiazoleChemistryHeLaTopoisomeraseStereochemistryConjugateDocking (animal)Human serum albuminA549 cellBinding constantIC50Combinatorial chemistryIn vitroBinding siteBiochemistryNursingMathematical analysisMedicineMathematicsCancer therapeutics and mechanismsCancer Treatment and PharmacologyPhotodynamic Therapy Research Studies