MiR-29b-3p promotes particulate matter-induced inflammatory responses by regulating the C1QTNF6/AMPK pathway
Jian Wang, Mengchan Zhu, Ling Ye, Cuicui Chen, Jun She, Yuanlin Song
Abstract
, miR-29b-3p antagomirs delivered via the tail vein prior to PM exposure significantly counteracted PM-induced miR-29b-3p upregulation and C1QTNF6 downregulation in lung tissues. Furthermore, miR-29b-3p inhibition alleviated inflammatory cells infiltration and pro-inflammatory cytokines secretion in the lung of PM-exposed mice. These findings firstly revealed that miR-29b-3p acted as a novel modulator of PM-induced inflammatory responses by targeting the C1QTNF6/AMPK signaling pathway, which contributes to a better understanding of the biological mechanisms underlying adverse PM-induced respiratory health effects.
Topics & Concepts
AMPKParticulatesInflammationCell biologyChemistryMedicineBiologyInternal medicineProtein kinase APhosphorylationOrganic chemistryMicroRNA in disease regulationCircular RNAs in diseases