Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation
Heyu Song, Shaoyan Xi, Yingling Chen, Suravi Pramanik, Jiping Zeng, Shrabasti Roychoudhury, Hannah L. Harris, Anum Akbar, Salma Elhag, Donald W. Coulter, Sutapa Ray, Kishor K. Bhakat
Topics & Concepts
DNA repairCancer researchCisplatinMedulloblastomaRadiation sensitivityHistoneDNA damageRadiation therapyChemotherapyBiologyMedicineInternal medicineDNAGeneticsPhysicsNuclear physicsIrradiationDNA Repair MechanismsGenomics and Chromatin DynamicsPARP inhibition in cancer therapy