Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and β-hydroxy β-methylbutyric acid across multiple organs in the pig
Gabriëlla A. M. Ten Have, Lisa T. Jansen, Marieke G. Schooneman, M.P. Engelen, Nicolaas E.P. Deutz
Abstract
Branched-chain amino acids (BCAA) and their metabolites the branched-chain keto acids (BCKA) and β-hydroxy β-methylbutyric acid (HMB) are involved in the regulation of key signaling pathways in the anabolic response to a meal. Substantial differences are present in (inter)organ metabolism and transport among the BCAA and its metabolites BCKA and HMB. The presented data in a translation animal model are relevant for the future development of optimized clinical nutrition.
Topics & Concepts
Amino acidAnabolismMetabolismBranched-chain amino acidBiologyChain (unit)Flux (metallurgy)BiochemistryChemistryInternal medicineLeucineMedicinePhysicsOrganic chemistryAstronomyDiet and metabolism studiesAdipose Tissue and MetabolismMuscle metabolism and nutrition