Amino acid sequence determines the adjuvant potency of a<scp>d</scp>-tetra-peptide hydrogel
Yiming Zhang, Zhiwen Hu, Xinxin Li, Yinghao Ding, Zhenghao Zhang, Xiang-Yang Zhang, Wenting Zheng, Zhimou Yang
Abstract
. Notably, Gel-gffy had the strongest immunostimulatory activity. Our findings demonstrate that both the position and number of aromatic amino acids are crucial in determining the adjuvant potency of Gel-gffy, thus providing a valuable insight into designing peptide hydrogels as vaccine adjuvants.
Topics & Concepts
PeptideAdjuvantOvalbuminChemistryAmino acidPeptide sequenceCircular dichroismBiochemistryEpitopeImmune systemMolecular biologyAntibodyBiologyImmunologyGeneImmunotherapy and Immune ResponsesAntimicrobial Peptides and ActivitiesImmune Response and Inflammation