N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance
Noa Liberman, Zach Klapholz O’Brown, Andrew Earl, Konstantinos Boulias, Maxim V. Gerashchenko, Simon Yuan Wang, Colette Fritsche, Paul-Enguerrand Fady, Anna Dong, Vadim N. Gladyshev, Eric Lieberman Greer
Abstract
to increase production of eicosanoids, and blocking this pathway increases stress resistance. This study suggests that ribosome methylation can facilitate selective translation, providing another layer of regulation of the stress response.
Topics & Concepts
MethylationRibosomal RNATranslation (biology)RibosomeBiologyBiochemistryCell biologyRNAMutantAdenosineMessenger RNAGeneRNA modifications and cancerEpigenetics and DNA MethylationRNA Research and Splicing