Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
Jasna Šuput Omladič, Anka Slana Ozimič, Andrej Vovk, Dušan Šuput, Grega Repovš, Klemen Dovč, Nataša Bratina, Magdalena Avbelj Stefanija, Tadej Battelino
Abstract
OBJECTIVE To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). RESULTS Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. CONCLUSIONS Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.