MicroRNA-217: A regulator of human cancer
Shuai Zhou, Chao Zhu, Qing Pang, Hui Chun Liu
Abstract
As highly conserved non-coding RNAs of approximately 18-24 nucleotides, microRNAs (miRNAs) regulate the expression of target genes. Multiple studies have demonstrated that miRNAs participate in the regulation of human cancer. MircoRNA-217 (miR-217) participates in the regulation of various tumors by specifically binding target genes and post-transcriptional regulation. In recent years, there have been numerous reports about miR-217 in tumor progression. MiR-217 is known mainly as a tumor suppressor, although some studies have shown that it functions as an oncomiR. Here, we review the current research related to miR-217, including its role in tumor progression and the molecular mechanisms.
Topics & Concepts
OncomirmicroRNARegulatorSuppressorBiologyRegulation of gene expressionGeneTranscriptional regulationComputational biologyTumor progressionCancer researchGene expressionGeneticsMicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseases