BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis
Takamitsu Maruyama, Ronay Stevens, Alan P. Boka, Laura DiRienzo, Connie Shinru Chang, Hsiao‐Man Ivy Yu, Katsuhiko Nishimori, Clinton Morrison, Wei Hsu
Abstract
in mice caused precocious differentiation, leading to craniosynostosis initiated at the suture midline, which is the stem cell niche. We found that BMPR1A is a cell surface marker of human SuSCs. Using an ex vivo system, we showed that SuSCs maintained stemness properties for an extended period without losing the osteogenic ability. This study advances our knowledge base of congenital deformity and regenerative medicine mediated by skeletal stem cells.
Topics & Concepts
CraniosynostosisStem cellCraniofacialAnatomyBiologyCell biologyMedicineGeneticsHedgehog Signaling Pathway StudiesCraniofacial Disorders and Treatmentsdental development and anomalies