Key shifts in frontoparietal network activity in Parkinson’s disease
Ronen Sosnik, Firas Fahoum, Zoya Katzir, Anat Mirelman, Inbal Maidan
Abstract
We aimed to study the effect of Parkinson's disease (PD) and motor-cognitive load on the interplay between activation level and spatial complexity. To that end, 68 PD patients and 30 controls underwent electroencephalography (EEG) recording while executing visual single- and dual- Go/No-go tasks. The EEG underwent source localization, followed by parcellation of the neural activity into 116 regions of interest. We observed alterations in activity within a distributed network of brain areas associated with attention and inhibition operations, including a circuit pathway connecting frontal and temporal/parietal regions and the limbic network. The alterations in activity were associated with task complexity (single- or dual- task) and group (PD or controls) and encompassed spatial, temporal and spectral dimensions. These results elucidate electrophysiological alterations in four core aspects of brain activity associated with motor-cognitive function in PD patients and hold potential implications for future studies involving adaptive electrical interventions.