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A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Roeland Lameris, Adam Shahine, Daniel G. Pellicci, Adam P. Uldrich, Stéphanie Gras, Jérôme Le Nours, Richard W.J. Groen, Jana Vree, Scott J. J. Reddiex, Sergio M. Quiñones‐Parra, Stewart K. Richardson, Amy R. Howell, Sonja Zweegman, Dale I. Godfrey, Tanja D. de Gruijl, Jamie Rossjohn, Hans J. van der Vliet

2020Nature Cancer38 citationsDOI

Topics & Concepts

CD1DNatural killer T cellT-cell receptorCD1Major histocompatibility complexEpitopeBiologyMHC class IAntigenCell biologyT cellSingle-domain antibodyImmunologyAntibodyMolecular biologyChemistryImmune systemCD8Immune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response | Litcius