Irf5 siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury
Wataru Kawase, Daisuke Kurotaki, Yuta Suzuki, Hiroshi Ishihara, Tatsuma Ban, Go Sato, Juri Ichikawa, Hideyuki Yanai, Tadatsugu Taniguchi, Kappei Tsukahara, Tomohiko Tamura
Abstract
siRNA-loaded LNPs compared to those injected with control siRNA-loaded LNPs. Our results suggest that administering biodegradable LNPs to deliver siRNA is a promising strategy for treating inflammatory disorders.
Topics & Concepts
Concanavalin APharmacologyChemistryLiver injuryMedicineBiochemistryIn vitroRNA Interference and Gene DeliveryAnimal Virus Infections StudiesSARS-CoV-2 and COVID-19 Research