A biotin-guided fluorescent probe for dual-mode imaging of viscosity in cancerous cells and tumor tissues
Mingguang Ren, Qingyu Xu, Shoujuan Wang, Lu Liu, Fangong Kong
Abstract
A cancer cell targeted fluorescent viscosity probe has been designed and synthesized to specifically visualise viscosity changes in biotin receptor (BiR) positive cells over biotin negative cells via dual-mode fluorescence imaging: fluorescence intensity mode and fluorescence lifetime mode.
Topics & Concepts
FluorescenceBiotinDual modeChemistryViscosityTumor cellsOptical imagingBiophysicsMaterials scienceCancer researchBiologyBiochemistryOpticsPhysicsEngineeringAerospace engineeringComposite materialAnalytical Chemistry and SensorsMolecular Sensors and Ion DetectionNanoplatforms for cancer theranostics