PHB2 promotes tumorigenesis <i>via</i> RACK1 in non-small cell lung cancer
Bin Wu, Ning Chang, Hangtian Xi, Jie Xiong, Ying Zhou, Yingtong Wu, Shuo Wu, Ning Wang, Hongyu Yi, Yun Song, Lihua Chen, Jian Zhang
Abstract
Our results reveal the effects of PHB2 on tumorigenesis and its regulation of RACK1 and RACK1-associated proteins and downstream signaling in NSCLC. We believe that the crosstalk between PHB2 and RACK1 provides us with a great opportunity to design and develop novel therapeutic strategies for NSCLC.
Topics & Concepts
CarcinogenesisLung cancerCancer researchChemistryCancerCell biologyMedicineBiologyPathologyInternal medicineEpigenetics and DNA MethylationGenetic factors in colorectal cancerCancer-related Molecular Pathways