Visible-Light-Triggered Synthesis of <i>N</i>-α-Ketoacylated Sulfoximines by Denitrogenative and Oxidative Functionalization of Vinyl Azides
S. SARKAR, Satyajit Pal, Sougata Santra, Grigory V. Zyryanov, Adinath Majee
Abstract
We have introduced a sulfoximidation reaction initiated by visible light between α-phenyl vinyl azides and NH-sulfoximines. The cost-effective and readily accessible hypervalent iodine reagent (PIDA) easily promoted the oxidative sulfoximidation process to afford N -α-ketoacylated sulfoximines in good to high yields, involving the formation of two new C–O bonds and one C–N bond. Additionally, the protocol offers noteworthy advantages, including its metal-free and photocatalyst-free reaction and its broad substrate compatibility.
Topics & Concepts
ChemistrySurface modificationOxidative phosphorylationCombinatorial chemistryOrganic chemistryBiochemistryPhysical chemistrySynthesis and Catalytic ReactionsRadical Photochemical ReactionsCatalytic C–H Functionalization Methods