Construction of C(sp<sup>2</sup>)–Si Bonds via Ligand-Promoted C–C Bonds Cleavage of Unstrained Ketones
Xing Wang, Zhenyu Wang, Xu Zhang, Hui Xu, Hui‐Xiong Dai
Abstract
Herein, we report an efficient palladium-catalyzed silylation of aryl and alkenyl ketones via C-C bond cleavage and C-Si bond formation. This protocol features high efficiency and broad substrate scope. Further applications in the late-stage diversification of biologically important molecules demonstrate the synthetic utility of this method.
Topics & Concepts
ChemistryBond cleavagePalladiumSilylationCleavage (geology)ArylMoleculeCatalysisStereochemistryLigand (biochemistry)Combinatorial chemistryOrganic chemistryReceptorEngineeringGeotechnical engineeringAlkylFracture (geology)BiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistry