Inhibition of Sirt3 activates the cGAS-STING pathway to aggravate hepatocyte damage in hepatic ischemia–reperfusion injury mice
Erliang Kong, Yang Zhang, Xuqiang Geng, Yuanyuan Zhao, Wei Lee Yue, Xudong Feng
Topics & Concepts
IRF3HepatocyteGene knockdownSIRT3InflammationReperfusion injuryIn vivoLiver injuryBiologyCancer researchPharmacologyImmunologyMedicineIschemiaApoptosisInternal medicineImmune systemIn vitroInnate immune systemSirtuinBiochemistryBiotechnologyAcetylationGeneinterferon and immune responsesInflammasome and immune disordersAutophagy in Disease and Therapy