Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity
Romana R. Gerner, S Macheiner, Simon Reider, Kerstin Siegmund, Felix Grabherr, Lisa Mayr, Bernhard Texler, Patrizia Moser, Maria Effenberger, H Schwaighofer, Alexander R. Moschen, Brigitte Kircher, Herbert Oberacher, Robert Zeiser, Herbert Tilg, David Nachbaur
Topics & Concepts
NAD+ kinaseNicotinamide phosphoribosyltransferaseCancer researchBiologyNicotinamide adenine dinucleotideHaematopoiesisLeukemiaGraft-versus-host diseaseNicotinamideNicotinamide mononucleotideImmunologyFOXP3Stem cellEx vivoCell biologyEnzymeBiochemistryImmune systemIn vitroCAR-T cell therapy researchCytomegalovirus and herpesvirus researchImmune Cell Function and Interaction