Synthesis of multi-substituted 1,2,4-triazoles utilising the ambiphilic reactivity of hydrazones
Haruo Matsuzaki, Norihiko Takeda, Motohiro Yasui, Mayuko Okazaki, Seishin Suzuki, Masafumi Ueda
Abstract
-alkyl-triazoles in high yields. The synthetic utility of multi-substituted triazoles was also demonstrated by further transformations.
Topics & Concepts
Reactivity (psychology)AlkylCycloadditionChemistryNucleophileAlkylationChlorideCombinatorial chemistrySequence (biology)Medicinal chemistryOrganic chemistryCatalysisBiochemistryPathologyMedicineAlternative medicineClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation