Interaction of aliphatic amino acids with zwitterionic and charged lipid membranes: hydration and dehydration phenomena
Nishu Kanwa, Soumya De, Avijit Maity, Anjan Chakraborty
Abstract
of amino acids in the vicinity of the lipid membranes and solvation and desolvation processes in the light of recent computer simulations. We also find that hydrogen bonding plays a significant role in governing the interaction of aliphatic amino acids with zwitterionic lipid membranes. The more polar serine bearing a hydroxyl group at the terminal carbon offers a stronger interaction with the lipid bilayer membranes as compared to its analogues leucine and valine, which are hydrophobic in nature.
Topics & Concepts
MembraneChemistryAmino acidAspartic acidLipid bilayerValineGlutamic acidSerineBilayerLeucineOrganic chemistryBiochemistryEnzymeLipid Membrane Structure and BehaviorSpectroscopy and Quantum Chemical StudiesMolecular Sensors and Ion Detection