Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
Sandeep Batra, Anthony J Ross
Abstract
Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of transplantation and precision genomics, and outline emerging targets and concepts in this rare entity.
Topics & Concepts
Risk stratificationMedicinePhenotypeIntensive care medicineClinical trialGenomicsTransplantationBioinformaticsPathologyInternal medicineBiologyGeneticsGeneGenomeAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of Life