Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
Sophie D. Adams, Judit Csere, Gisela D’Angelo, Edward Carter, Maryse Romao, Teresa Arnandis, Martin Dodel, Hemant M. Kocher, Richard Grose, Graça Raposo, Faraz K. Mardakheh, Susana A. Godinho
Abstract
EVs secreted by cancer cells with amplified centrosomes influence the bidirectional communication between the tumor cells and the surrounding stroma to promote malignancy.
Topics & Concepts
CentrosomeBiologyCell biologySecretionLysosomeCancer cellMicrovesiclesExtracellularPancreatic cancerCellCancerBiochemistryCell cyclemicroRNAGeneEnzymeGeneticsExtracellular vesicles in diseaseMicroRNA in disease regulationPhagocytosis and Immune Regulation