Minimalistic bis-triarylpyridinium cations: effective antimicrobials against bacterial and fungal pathogens
Ana M. López-Fernández, J.C. Lacerda Neto, Rosa de Llanos, Juan F. Miravet, Francisco Galindo
Abstract
show that 1a has a strong mitochondrial activity, causing a remarkable mitochondrial membrane depolarization in this organelle. Taken together, this study positions triarylpyridinium cations-previously unexplored as antimicrobials-as promising candidates for future drug development, especially in light of the growing concern over drug-resistant microorganisms.
Topics & Concepts
AntimicrobialMicrobiologyChemistryBiologyAntimicrobial Resistance in StaphylococcusSynthesis and biological activitySynthesis and Biological Evaluation