Analytical Sensitivity of Eight Different SARS-CoV-2 Antigen-Detecting Rapid Tests for Omicron-BA.1 Variant
Meriem Bekliz, Kenneth Adea, Olha Puhach, Francisco Rodríguez, Stéfane Marques Melancia, Stéphanie Baggio, Anna‐Rita Corvaglia, Frédérique Jacquérioz, Catia Alvarez, Manel Essaidi-Laziosi, Camille Escadafal, Laurent Kaiser, Isabella Eckerle
Abstract
Sensitivity for detecting Omicron-BA.1 shows high heterogenicity between Ag-RDTs, necessitating a careful consideration when using these tests to guide infection prevention measures. Analytical and retrospective testing is a proxy and timely solution to generate rapid performance data, but it is not a replacement for clinical evaluations, which are urgently needed. Biological and technical reasons for detection failure by some Ag-RDTs need to be further investigated.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Antigen2019-20 coronavirus outbreakSensitivity (control systems)VirologyBiologyGeneticsMedicinePathologyEngineeringOutbreakDiseaseInfectious disease (medical specialty)Electronic engineeringSARS-CoV-2 detection and testingBiosensors and Analytical DetectionSARS-CoV-2 and COVID-19 Research