Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses
Vikas Saxena, Wenji Piao, Lushen Li, Christina Paluskievicz, Yanbao Xiong, Thomas Simon, Ram Lakhan, C. Colin Brinkman, Sarah L. Walden, Keli L. Hippen, Marina WillsonShirkey, Young Shin Lee, Chelsea Wagner, Bruce R. Blazar, Jonathan S. Bromberg
Abstract
and resist exTreg conversion in an adenosine-receptor-2A-dependent fashion. Human Tregs migrating across human LECs behave similarly. These molecular interactions can be targeted for therapeutic manipulation of immunity and suppression.
Topics & Concepts
LymphotoxinLymphotoxin beta receptorLymphatic systemReceptorAdenosineAdenosine receptorLymphatic EndotheliumCell biologyLymphotoxin alphaImmunologyBiologyChemistryInternal medicineCancer researchMedicineEndocrinologyAgonistLymphatic System and DiseasesCircadian rhythm and melatoninApelin-related biomedical research