Acid-catalyzed cleavage of C–C bonds enables atropaldehyde acetals as masked C2 electrophiles for organic synthesis
Shaomin Chen, Minghao Li, Yanlong Gu
Abstract
2' substitution, in which the atropaldehyde acted as an electrophile; and (ii) oxidative cleavage of the carbon-carbon bond of the generated phenylacetaldehyde-type products. Compared with literature methods, the present protocol not only avoided the use of expensive noble metal catalysts, but also enabled a simple operation.
Topics & Concepts
ElectrophileChemistryCleavage (geology)CatalysisTandemBond cleavageCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryComposite materialEngineeringGeotechnical engineeringFracture (geology)Materials scienceCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsAsymmetric Synthesis and Catalysis